It is a benign noncancerous tumor that most often develops in older children and young adults under 30 years of age. Chondromyxoid fibroma cmf is a rare entity, representing chondromyxoid fibroma cmf is an exceedingly rare benign tumor of cartilaginous origin accounting for less than 1% of all primary bone tumors and less than 2% of benign bone tumors. In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues. Five cases, with the final diagnosis of chondromyxoid fibroma of the calcaneal bone are included in this report.
Chondromyxoid fibroma of the petrygopalatine space the. We believe it to be the second case of congenital cmf that has been documented, and the third case of cmf arising in the ethmoid. Wenzel departments of radiology and oral and maxillofacial surgery, royal dental college, aarhus, denmark received 4 june 1990 and in final form 10 august 1990 a case of recurrence of a chondromyxoid fibroma 3 years after its surgical removal is presented. Chondromyxoid fibroma cmf is one of the rarest of bone tumors, accounting for less than 1% of all bone tumors. Pdf chondromyxoid fibroma of the lateral malleolus. Chondromyxoid fibroma is an extremely rare, benign cartilaginous tumor, which might be misdiagnosed as.
We report a case of a 35yearold female with a 3 month history of lower back pain after sustaining a fall on her sacrumcoccyx presenting with a progressive complaint of localized lower back pain, occasional urinary retention without incontinence, gluteal hypesthesia, and. Chondromyxoid fibroma, cmf, is the least common benign cartilaginous tumor composed of chondroid and myxoid matrix. Chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilagelike matrix, accounting for approximately 1% of all bone tumors. Chondromyxoid fibroma is a benign cartilaginous neoplasm first distinguished from other cartilaginous tumors by jaffe and lichenstein in 1948 1, 2. Chondromyxoid fibroma cmf is a rare cartilaginous tumor of bone. Who classification of tumours of soft tissue and bone. Chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up case description. Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. Article information, pdf download for chondromyxoid fibroma of the. Chondromyxoid fibroma cmf is a rare, benign neoplasm of the chondroid, myxoid, and fibrous tissue.
Chondromyxoid fibroma is a rare bone neoplasm characterized by chondral, myxoid and fibrous differentiation. Chondromyxoid fibroma involving the sphenoid sinus. It is rare in the jaws and skull bones, where only about 2% of all cases have been reported. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. Chondromyxoid fibroma is a rare bone tumor found most prevalently in long bones, so its presence at. Chondromyxoid fibromas account for download as ppt, pdf, txt or read online from scribd. It accounts for less than 1% of all bone tumors and approximately 95% of these cases are seen in metaphysis of long bone. Pdf chondromyxoid fibroma of the finger researchgate. It is associated with high local recurrence rates with a small risk chondromyxoid fibroma cmf is a rare, benign bone tumour. Jaffe and lichtenstein first described the condition in 1943.
Chondromyxoid fibroma of the femur can not be differentiated. Chondromyxoid fibroma of the maxillofacial region is typically seen in patients. Chondromyxoid fibroma is a rare benign primary bone tumor composed of immature myxoid. Pdf congenital chondromyxoid fibroma of the ethmoid. This is an example of a rare tumor in an unusual location. We report the diagnosis and management of a 31yearold male with a large, incidentally discovered cmf originating from the sphenoid sinus. More than half of the cases develop in the second and third decades of life.
Chondromyxoid fibroma of the petrygopalatine space volume 90 issue 10 n. It frequently involves the metaphysis of the long tubular bones in the second and third decades of life and also occurs in the flat bones, mainly the ileum, and the small bones of the hand and foot. The primary pitfall in the histopathologic diagnosis of cmf is confusion with a highgrade chondrosarcoma, owing to the atypical stellate and spindled cells set within a chondromyxoid background. A rare case of juxtacortic chondromyxoid fibroma in. However, the case presented here is an extremely rare case as the tumor affected the middle and upper segment of the humerus.
Chondromyxoid fibroma occurs mostly in the long bones of appendicular skeleton, but occurrence in craniofacial and gnathic regions is even rare. Chondromyxoid fibromas cmfs are rare benign chondroidmyxoid matrix producing tumors that occur in metaphyses of long tubular bones. Chondromyxoid fibroma cmf is a rarely encountered benign bone chondroid tumor. World health organization classification of tumors. Chondromyxoid fibroma cmf is a benign cartilaginous neoplasm first distinguished from other cartilaginous tumors by jaffe and lichenstein in 1948. It usually affects the metaphyseal region of long bones of patients in their first or second decade of life.
However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. Pdf chondromyxoid fibroma of the mandible jasna spicek. Hyunsoo kim 1, w onhee jee 1, kyungnam ryu 2, kilho cho 3, jinsuck suh 4. Chondromyxoid fibroma rare, slow growing, benign cartilagenous tumor chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. A rare and benign chondrogenic lesion characterized by variable amounts of chondroid, fibromatoid and myxoid elements. Chondromyxoid fibroma of the maxillofacial region is typically seen in. This report describes a congenital case of chondromyxoid fibroma cmf arising from the ethmoid bone. Chondromyxoid fibroma cmf is a relatively uncommon benign bone. Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. Background chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up download full text in pdf download. Chondromyxoid fibroma cmf is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. Frank, dds,d iowa city, iowa university of iowa chondromyxoid fibroma is a benign tumor of bone that is. Chondromyxoid fibroma cmf is a rare benign cartilaginous bone tumor with a characteristic lobular architecture and chondromyxoid background, this tumor. Various treatment options are available for this tumour and recurrences have been reported following surgery.
A distinctive benign tumor likely to be mistaken especially for chondrosarcoma. An additional peak of incidence has been observed between 50 and 70 years of age. Cytogenetic analysis of a scapular chondromyxoid fibroma. Chondromyxoid fibroma cmf is a rare benign cartilaginous bone tumor with a characteristic lobular architecture and chondromyxoid background, this tumor account for 5% of all maxillofacial bone tumors. Chondromyxoid fibroma cmf is a benign cartilaginous. We present a new case of cmf arising from the sternum of a 47yearold man and compare it with the previous cases. Only 2 of the 50 chondromyxoid fibromas included in their study occurred in the skull. The classical site is the upper onethird of the tibia, which accounts for 25% of all cases, with the small tubular bones of. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or. Chondromyxoid fibroma is a benign tumor composed of spindle or stellate cells forming lobules and with abundant myxoid andor chondroid intercellular material. Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts. The classic site of involvement is the metaphyseal region of long tubular bones. Chondromyxoid fibroma cmf is a rare benign bone tumor and represents less than 1% of primary bone tumors.
It characteristically affects the lower extremity long bones, although it may rarely arise within the craniofacial skeleton. Primary cmf of the sternum is quite rare, with only four cases documented in the. Chondromyxoid fibroma cmf is a rare, benign bone tumour. Most chondromyxoid fibromas are located in the metaphyseal region of long bones 60%, and may extend to the epiphyseal line and even rarely abut the articular surface 3,12. Chondromyxoid fibroma is a benign tumor of bone that is characterized by chondroid and myxoid differentiation and by ultrastructural and immunohistochemical evidence of chondral origin. This article documents the first reported case of a chondromyxoid fibroma involving the c2 vertebrae with cranial cervical instability.
Metaphysis of long bones is the most common location of this tumor. Pdf on may 1, 2014, somin hwang and others published chondromyxoid fibroma of the. It is associated with high local recurrence rates with a small risk chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation. Primary chondromyxoid fibroma cmf of the sternum is quite rare with only four cases documented in the literature. Chondromyxoid fibroma cmf is a relatively uncommon benign bone tumor of cartilaginous differentiation. An 11yearold girl presented to our opd with complaints. Chondromyxoid fibroma of rib with a novel chromosomal translocation. Chondromyxoid fibroma of the sternum sciencedirect. Roentgenography, mri and ultrasound can suggest the diagnosis.
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